Platelet Fc?RIIA in immunity and thrombosis: Adaptive immunothrombosis

Abstract Sepsis and autoimmune diseases remain major causes of morbidity mortality. The last decade has seen a new appreciation platelets in host defense, both immunity thrombosis. Platelets are first responders the blood to microbes or non?microbial antigens. role physiologic is counterbalanced by their pathology, for example, microvascular encounter antigens via innate adaptive immune processes; also help shape subsequent response. Fc?RIIA receptor complexes opsonized IgG pentraxins, expressed humans platelets, granulocytes, monocytes macrophages. With consideration roles Fc receptors, response autoantigens can be called immunothrombosis. Here we review newer developments involving platelet humanized mice thrombosis, with special attention heparin?induced thrombocytopenia, systemic lupus erythematosus, bacterial sepsis. Human genetic diversity receptors utility mouse models highlighted.